Temperature and mortality are linked. There is a short-term increase in mortality when temperatures are at their hottest or coldest – a phenomenon known as a “U-shaped relationship”. Inserm researchers at the Institute for Advanced Biosciences (Inserm/Université Grenoble Alpes/CNRS) and the Inserm Epidemiology Center on Medical Causes of Death (CépiDc) have sought to determine the […]
Some endocrine disruptors have already been associated with an impaired quality of tooth enamel. After demonstrating the harmful effects of bisphenol A on tooth development, a team of researchers from Inserm, Université Paris Cité and Sorbonne Université, at the Cordeliers Research Center in Paris, in collaboration with CNRS went on to look at the effects of DEHP, an endocrine disruptor in the phthalate family, on dental development.
A new study shows for the first time that 25% of adults in France are affected by some form of hearing loss. Disabling hearing loss, which is more severe, is thought to affect 4% of adults. This prevalence varies with age and other factors (standard of living, noise exposure at work, cardiovascular diseases, etc.), which are described in the study. The scientists have found that hearing aids remain largely...
While bacteriophages – viruses that kill bacteria – could be a solution for fighting antibiotic-resistant pathogens, various obstacles stand in the way of their clinical development. To overcome them, researchers have developed a model to better predict the efficacy of phage therapy and possibly develop more robust clinical trials.
Santé publique France et l’Inserm (Institut national de la santé et de la recherche médicale) signent aujourd’hui un accord visant à encadrer, renforcer et développer leur collaboration. Plusieurs thématiques prioritaires ont été identifiées pour les 5 prochaines années : maladies infectieuses émergentes et modélisation, facteurs environnementaux et santé, nutrition, inégalités sociales et santé périnatale. Cet accord permettra une alliance scientifique renforcée de la recherche avec la surveillance et la prévention-promotion...
Seasonal influenza is a major public health issue because it continues to remain associated with considerable mortality, particularly among people who are elderly, immunocompromised, or both. With vaccination and current treatments still being of limited efficacy, research teams are trying to develop new therapeutic approaches. Scientists have shown that in a context of influenza infection, a metabolite called succinate, which is naturally present in the body, has an antiviral...
In a new study, researchers investigated a receptor found on male germ cells that produce gametes, their aim being to find out more about its role in chemotherapy-related infertility. Their findings pave the way for a better understanding of male infertility and the development of treatments to reduce the risk of sterility from chemotherapy.
Dans une nouvelle étude, des scientifiques ont identifié, à partir des données de près de 26 000 volontaires de la cohorte Constances, quels symptômes persistants sont le plus fréquemment rapportés par les personnes ayant été infectées par le SARS-CoV-2 comparé au reste de la population. Il s’agit principalement de la perte de goût ou d’odorat, de gêne respiratoire ou de fatigue.
A very small percentage of people with HIV-1, known as "post-treatment controllers" (PTCs), are able to control their infection after interrupting all antiretroviral therapy. Understanding the fundamental mechanisms that govern their immune response is essential in order to develop HIV-1 vaccines, novel therapeutic strategies to achieve remission, or both. A recent study investigated the humoral immune response – also known as antibody-mediated immunity – in some PTCs in whom...
Researchers have studied the impact of individual sociodemographic, behavioral and health factors on the practice of daily physical activity in later life, using data from 3,896 participants of the Whitehall II cohort. This research highlights the complexity of individual barriers to an active lifestyle among older adults and suggests that this complexity should be better taken into account when redefining public health policies.