Jacobo Sitt firstname.lastname@example.org +33 (0) 1 57 27 43 17
How do we know whether a patient is conscious when he or she is unable to communicate? According to an Inserm study conducted in 127 patients aged 17 to 80, changes in heartbeat in response to sound stimulation is a good indicator of state of consciousness. This is what Inserm researcher Jacobo Sitt and his team, based at the Brain & Spine Institute (ICM) at Pitié-Salpêtrière Hospital, AP-HP, demonstrate in an article published in Annals of neurology. This easy-to-perform examination complements the existing tests and enables finer predictive diagnosis, useful for both doctors and the patient’s loved ones.
The study of consciousness disorders distinguishes the vegetative state, in which the patient is awake but not conscious, from the minimal state of consciousness, which involves a certain degree of consciousness. Distinguishing between these states is very important in order to establish a prognosis on the patient’s neurological outcome, inform the patient’s loved ones, and implement suitable treatment. The tools developed up until now to determine state of consciousness, such as the electroencephalogram (EEG), functional MRI or PET scan, all concentrate on the brain. These methods require either heavy equipment or complex analysis.
Researchers from Inserm have used a novel approach, which consists of exploring the interaction between the heart and the brain.
Previous studies revealed that the “unconscious” processes of the autonomic nervous system, such as breathing or heartbeat, could be modulated by conscious cognitive processes. The perception of external stimulation, auditory stimuli, for example, could therefore be expressed by an effect on cardiac activity, and all the more easily if the subject is conscious.
By studying the data of 127 patients in vegetative or minimally conscious states, researchers observed that cardiac cycles were indeed modulated by auditory stimulation only in conscious or minimally conscious patients. They also showed that these results complemented those obtained with an EEG. Combining these tests (cardiac and EEG) markedly improves performance when predicting a patient’s state of consciousness.
These findings open up new perspectives for an overall approach in evaluating patient state of consciousness. The researchers now wish to extend the scope to include other physiological signals modulated by conscious processes, such as breathing or pupil dilation, in order to develop a comprehensive tool for better bedside evaluation of patient state of consciousness.
The test involves playing sound sequences to the patient, which are repetitive to begin with and then, at random and infrequent intervals, present variations. During these variations, the researchers are able to determine whether there is a change in heartbeat, which would mean that the patient is aware of ambient sounds.
Firibastat is the first in a new class of antihypertensive drugs targeting the renin-angiotensin system in the brain. ...
Les personnes atteintes de neuropathie optique héréditaire de Leber perdent la vue dès l’adolescence avec un déclin soudain au niveau des deux yeux, jusqu’à la cécité. Alors que les options de traitements étaient jusqu’ici très limitées, des chercheurs à l’Institut de la ...
Brain-heart interactions reveal consciousness in non-communicating patients Federico Raimondo1,2,3,4 ; Benjamin Rohaut MD, PhD5,6 ; Athena Demertzi PhD3,5; Melanie Valente3,5; Denis Engemann3,5,7,8; Moti Salti PhD9; Diego Fernandez Slezak PhD1,2; Lionel Naccache MD, PhD3,4,5,6,10; Jacobo D. Sitt MD, PhD3,5