.Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds Vanessa Delfosse1-3,13, Béatrice Dendele3-6,13, Tiphaine Huet1-3,13, Marina Grimaldi3-6, Abdelhay Boulahtouf3-6, Sabine Gerbal-Chaloin3,7, Bertrand Beucher3,8,9, Dominique Roecklin10, Christina Muller10, Roger Rahmani11, Vincent Cavaillès3-6, Martine Daujat-Chavanieu3,7,12, Valérie Vivat10, Jean-Marc Pascussi3,8,9, Patrick Balaguer3-6,14* & William Bourguet1-3,14* 1 Inserm U1054, Montpellier, France; 2 CNRS UMR5048, Centre de Biochimie Structurale, Montpellier, France; 3 Université de Montpellier, Montpellier, France; 4 IRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier, France; 5 Inserm, U1194, Montpellier, France; 6 ICM, Institut régional du Cancer de Montpellier, Montpellier, France; 7 Inserm U1040, Montpellier, France; 8 Inserm U661, Montpellier, France; 9 CNRS UMR5203, Institut de Génomique Fonctionnelle, Montpellier, France; 10 NovAliX, Illkirch, France; 11 INRA UMR 1331, TOXALIM, Sophia-Antipolis, France; 12 CHU de Montpellier, Institut de Recherche en Biothérapie, Montpellier, France 13 These authors equally contributed to this work 14 These authors jointly supervised this work Nature Communication, 3 september 2015