Despite the concern of an explosion of dementia cases in an aging population over the next few decades, a new study, based on data from the Framingham Heart Study (FHS), suggests that the rate of new cases of dementia actually may be decreasing.
These findings, which appear in the New England Journal of Medicine, provide hope that some cases of dementia might be preventable or delayed and encourages funding agencies and the scientific community to further explore demographic, lifestyle and environmental factors underlying this positive trend.
It is believed that the number of Americans with Alzheimer’s disease and other dementias will grow each year as the size and proportion of the U.S. population age 65 and older continues to increase. By 2025 the number of people age 65 and older with Alzheimer’s disease is estimated to reach 7.1 million — a 40 percent increase from the 5.1 million aged 65 and older affected in 2015. By 2050, the number of people in this age population with Alzheimer’s disease may nearly triple, from 5.1 million to a projected 13.8 million, barring the development of medical breakthroughs to prevent or cure the disease.
Worldwide, the World Health Organization (WHO) estimates that 47.5 million people have dementia in the world and the total number of people with dementia is projected to reach 75.6 million in 2030 and almost triple by 2050 to 135.5 million.
FHS participants have been continuously monitored for the occurrence of cognitive decline and dementia since 1975. Thanks to a rigorous collection of information, FHS researchers have been able to diagnose Alzheimer’s disease and other dementias using a consistent set of criteria over the last three decades. These sources of information include FHS exams, outside clinical records, interviews with family members, and the examination of participants suspected of having a neurological problem by neurologists and neuropsychologists.
Researchers looked at the rate of dementia at any given age and attempted to explain the reason for the decreasing risk of dementia over a period of almost 40 years by considering risk factors such as education, smoking, blood pressure and medical conditions including diabetes, high blood pressure or high cholesterol among many others.
Looking at four distinct periods in the late 1970s, late 1980s, 1990s and 2000s, the researchers found that there was a progressive decline in incidence of dementia at a given age, with an average reduction of 20 percent per decade since the 1970s, when data was first collected. The decline was more pronounced with a subtype of dementia caused by vascular diseases, such as stroke. There also was a decreasing impact of heart diseases, which suggests the importance of effective stroke treatment and prevention of heart disease. Interestingly, the decline in dementia incidence was observed only in persons with high school education and above.
“Currently, there are no effective treatments to prevent or cure dementia; however, our study offers hope that some of the dementia cases might be preventable — or at least delayed — through primary (keep the disease process from starting) or secondary (keep it from progressing to clinically obvious dementia) prevention,” explained corresponding author Sudha Seshadri, MD, professor of neurology at Boston University School of Medicine and FHS senior investigator. “Effective prevention could diminish in some measure the projected explosion in the number of persons affected with the disease in the next few decades,” she added.
The FHS consistently has been shown to be a reliable source of data. However the authors concede that the sample population is overwhelmingly of European ancestry and that further studies are needed to extend the findings to other populations. In addition, the authors also did not look at the effects of key variables such as changes in diet and exercise.
Despite these limitations, “it is very likely that primary and secondary prevention and better management of cardiovascular diseases and stroke, and their risk factors, might offer new opportunities to slow down the currently projected burden of dementia for the coming years ” add Carole Dufouil, Inserm research director in Bordeaux (France).
Yet, the authors warn that this does not mean that the total number of persons with dementia will decrease anytime soon. Since baby boomers are aging and people are living longer, the burden of dementia will continue to grow.
This particular type of study requires an enormous amount of data collected over many years on the same persons, and the study was only possible thanks to the generosity and dedication of FHS participants, who contribute their time and data with a missionary zeal. There is a plaque in the center of Framingham town that states, ‘Framingham, the town that changed America’s heart!’ released at the 50th anniversary of the FHS in 1998. Now the town can claim some credit for changing America’s brain health as well.
The study was also possible thanks to the work of earlier generations of researchers, as well as colleagues at the FHS who contribute to ongoing data collection. This study was carried out in collaboration between Inserm researchers at the Bordeaux School of Public Health / Inserm in France and Boston University School of Medicine.
Funding for this study was provided by the National Heart, Lung and Blood Institute’s Framingham Heart Study (Contract No. N01-HC-25195 and No. HHSN268201500001I) and by grants from the National Institute of Aging (AG008122 and AG033193) and National Institute on Neurological Disorders and Stroke (NS017950).
Dementia Incidence over the Last Three Decades in the Framingham Study
Claudia L. Satizabal, Ph.D.,Alexa S. Beiser, Ph.D., Vincent Chouraki, M.D., Ph.D., Geneviève Chêne, Ph.D., Carole Dufouil, Ph.D., Sudha Seshadri, M.D.
From the Boston University School of Medicine, Boston, MA (C.L.S., A.S.B., V.C., S.S.); Framingham Heart Study, Framingham, MA (C.L.S., A.S.B., V.C., S.S.); and Inserm U897 and CIC 1401-EC (Clinical Epidemiology) and University of Bordeaux, Isped (Bordeaux School of Public Health), both in Bordeaux, France (G.C., C.D.).
New England Journal of Medicine, 10 février 2016
DOI : 10.1056/NEJMoa1504327