- 2015
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Press releases - 24.02.2015
Preliminary results of the JIKI clinical trial to test the efficacy of favipiravir in reducing mortality in individuals infected by Ebola virus in Guinea.
Preliminary data from the JIKI clinical trial, which is testing the efficacy of favipiravir in reducing mortality associated with Ebola, provide two important pieces of information:
• absence of efficacy in individuals who arrive at treatment centres with a very high level of viral replication and who already have serious visceral involvement,
• and encouraging signs of efficacy in individuals arriving at treatment centres with a high or moderate level of viral replication, who have not yet developed overly severe visceral lesions.
With this classification into two groups, we have a much better understanding of Ebola virus disease, and can redefine the role of antiviral monotherapies in the therapeutic arsenal used against the disease.
The trial, sponsored by Inserm and funded by the European Commission from the Horizon 2020 Initiative under the project title REACTION, is supported by two NGOs, Médecins Sans Frontières/Doctors Without Borders (MSF) and Alliance for International Medical Action (ALIMA); two laboratory networks, Belgian First Aid and Support Team (B-FAST) and European Mobile Laboratory (EMLab); the French Red Cross, and the French Military Health Service.
These preliminary data are being presented on Wednesday 25 February as a late-breaking abstract at the CROI international conference (Conference on Retroviruses and Opportunistic Infections) in Seattle. -
News in brief - 23.02.2015
Long-term consequences of stress experienced in childhood
Exposure to stress during sensitive periods of development in childhood could alter the functioning of the various physiological systems and affect health in the long term. This has been revealed by a study conducted by the Inserm team led by Cyrille Delpierre, Inserm Research Fellow, and published in PNAS. Adverse experiences in childhood may take […]
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Press releases - 20.02.2015
Influenza: more than two million French affect
According to the weekly bulletin of the Sentinelles network, the incidence of influenza crossed the epidemic threshold last week
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What's on? - 20.02.2015
Influenza: more than two million French affect
According to the weekly bulletin of the Sentinelles network, the incidence of influenza is close to its peak. In 5 weeks, 2 044 000 persons had consulted their doctor. The rates of incidence has been estimated that 231 cases per 100,000 inhabitants. A figure that exceeds the epidemic threshold (179 cases per 100,000 inhabitants). At regional […]
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News in brief - 20.02.2015
Diabetes: fasting in the wrong place at the wrong time
During fasting, in order to cope with nutrient depletion, cells break down their own constituents, a process known as autophagy. Roméo Ricci’s team at the Institute of Genetics and Molecular and Cellular Biology (CNRS/Inserm/University of Strasbourg) has shown that, during fasting, the pancreatic beta cells, which are responsible for insulin secretion, do not compensate for […]
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Press releases - 18.02.2015
Severe asthma: gallopamil confirmed as a therapeutic approach
A team of Inserm researchers from the Cardio-Thoracic Research Centre of Bordeaux has demonstrated the clinical efficacy of gallopamil in 31 patients with severe asthma.
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Press releases - 17.02.2015
FameLab: the scientific communication competition returns to France !
For the second consecutive year, FameLab, the international scientific communication competition organised by the British Council and its partners, is coming back to France !
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What's on? - 17.02.2015
FameLab: the scientific communication competition returns to France !
For the second consecutive year, FameLab, the international scientific communication competition organised by the British Council and its partners, is coming back to France !Who is this competition for?Whether you are a young researcher, student or teacher of science, FameLab invites you to present your chosen subject for three minutes to a panel of professionals […]
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Press releases - 16.02.2015
Foetal growth restriction (FGR): assessment and impact of screening
An observational study carried out in France by Jennifer Zeitlin and her team, on over 14,000 women, shows that only 21% of infants with foetal growth restriction (FGR) had been suspected of having FGR during pregnancy.
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Press releases - 13.02.2015
Immune cells commit suicide to prevent allergy
Scientists from the CNRS, INSERM and Université de Limoges have demonstrated that the production of type E immunoglobulins (IgE) by B lymphocytes induces a loss in their mobility and the initiation of cell death mechanisms.