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2019 World Sickle Cell Awareness Day

12 Jun 2019 | By Inserm (Newsroom) | International day

Red blood cells, sickle shaped (Sickle Cell Disease) ©Inserm/Chevance de Boisfleury, Anne-Marie

Wednesday 19 June 2019 is World Sickle Cell Disease Day.

This is the most widespread genetic disorder in the world: It affects over five million people(1). It can have serious consequences—anaemia, episodes of pain—and may involve different organs or reduced resistance to certain infections.

From the physiological point of view, this disease of the blood is characterised by altered haemoglobin. Haemoglobin is the main constituent of the red blood cell. It is responsible for oxygen transport in the bloodstream, and its distribution to all the organs. The red blood cell becomes deformed, assumes a sickle shape (see illustration), and can no longer circulate through the blood vessels.

Research on sickle cell disease is currently aimed at improving treatments, by gene therapy and other means. Researchers are also studying the molecular mechanisms of the disease and the behaviour of abnormal haemoglobin.

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Unité Inserm 955 Institut Mondor de recherche biomedicale (IMRB)

Domaines d’expertise : Erythrocyte, Hémoglobine, Hémoglobinopathies, Drépanocytose, Thalassémie, Chimie des protéines

Téléphone : 01 49 81 35 78


Jacques Elion

Unité Inserm 1134 Biologie intégrée du globule rouge

Equipe/activité : Biologie des molécules d’adhérence et des transporteurs de la membrane érythroide

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