Research jointly conducted by investigators at Institut Gustave Roussy, Inserm, Institut Pasteur and INRA (French National Agronomic Research Institute) has led to a rather surprising discovery on the manner in which cancer chemotherapy treatments act more effectively with the help of the intestinal flora (also known as the intestinal microbiota).
A team of researchers at Inserm led by Cyril Herry (Inserm Unit 862, “Neurocentre Magendie,” Bordeaux) has just shown that interneurons located in the forebrain at the level of the prefrontal cortex are heavily involved in the control of fear responses. Using an approach combining in vivo recordings and optogenetic manipulations in mice, the researchers succeeded in showing that the inhibition of parvalbumin-expressing prefrontal interneurons triggers a chain reaction...
An international study conducted on mice and coordinated by researchers from Inserm, CNRS and Université Paris-Sud[1] has paved the way towards personalized chronotherapy treatments. In an article published in the journal Cancer Research, the team has shown that the timing of optimal tolerance to irinotecan, a widely used anti-cancer drug, varies by 8 hours depending on the sex and genetic background of mice. They then developed a mathematical model...
Multiple Sclerosis (MS) is a debilitating neurological disease which affects 80,000 individuals in France. At the moment, there is no known cause or cure. There are only treatments for the disease symptoms. Given the need to keep patients informed of progress in research, Inserm and Fondation ARSEP organise national meetings between researchers and patients every two years.
Launched two years ago by the French GPs Sentinelles network (a joint research unit involving Inserm and the Université Pierre et Marie Curie) and the French Institute for Public Health Surveillance, the GrippeNet.fr website is back for a third consecutive year.
In a lymphoma model, the scientists have been able to carry out real time in vivo imaging of the cellular events activated by the treatment and resulting in the destruction of tumor cells.
A new strategy for emergency anticoagulant treatment for patients with acute myocardial infarction has been put in place by a team led by Philippe-Gabriel Steg at Inserm Unit 698 (Haemostasis, Bioengineering, Immunopathology and Cardiovascular Remodelling), at Hôpital Bichat, AP-HP, Université Paris Diderot).
In a paper published on the British Medical journal, Patricia Dargent and her team at Inserm Unit 1018 (Center for Research In Epidemiology And Population Health (CESP) reveal that exercise programmes designed to prevent falls in older adults also appear to prevent injuries caused by falls.
The largest international study ever conducted on Alzheimer's disease, as part of the IGAP (International Genomics of Alzheimer Project) international consortium, coordinated by the joint research unit comprising Inserm, the Pasteur Institute at Lille-University Lille Nord de France 'Public health and molecular epidemiology of diseases associated with ageing' and LabEx DISTALZ, directed by Philippe Amouyel, has identified eleven new regions of the genome involved in the appearance of this...
Despite their efforts, many morbidly obese people continue to consume too much food (hyperphagia) compared to their reserves and their needs. And yet, the hunger hormone, called ghrelin, is most frequently found at a normal or even lower level in these patients. The Inserm Unit 1073 team "Nutrition, inflammation and dysfunction of the gut-brain axis" (Inserm/University of Rouen) has just explained this mechanism causing this paradoxical hyperphagia. Certain antibodies...
How can some people resist the attraction of immediate pleasures and pursue long-term goals, while others easily succumb and compromise their ultimate expectations? One secret factor might lie in the activity of a deep brain structure: the hippocampus.
