Researchers from the Institut Pasteur and Inserm discovered that innate effector cells – group 3 innate lymphoid cells – act not only during the early stages of infection but can also be trained to develop an innate form of immunological memory that can protect the host during reinfection.
Researchers describe how basophils respond to SARS-CoV-2 infection. They show that exposure to the virus activates them, leading to the production of certain cytokines and helping to reduce inflammation and promote the secretion of antibodies.
Annually over 50,000 bone marrow transplantations occur worldwide as a therapy for multiple cancerous and non-cancerous diseases. Yet, how this procedure gives rise to bone marrow-derived cells that engraft the brain, despite being absent in the normal brain, remains unknown. Scientists discovered how the host’s microglia, the brain’s innate immune cells, are replaced by bone marrow-derived macrophages. The key discovery was that transplantation chemotherapy eliminated the microglia’s regenerative capacity,...
A Swiss-French team that includes UNIGE scientists has discovered how to trigger apoptosis in leukaemia cells by disrupting their energy maintenance mechanism.
Monoclonal antibody therapy can be very effective in treating numerous illnesses, such as cancers, chronic inflammatory conditions, and infectious diseases. Researchers from Inserm, Université de Paris, Sorbonne Université and CNRS1 have designed and tested a new immunotherapy approach that uses pre-existing antibodies directed against the Epstein-Barr virus – part of the herpes family of viruses and present in over 95% of the world's population – in order to target...
Myotonic dystrophy type 1 (DM1) or Steinert’s disease is a rare and debilitating genetic neuromuscular disease affecting multiple organs and with a fatal outcome. No treatment is available at present. Encouraged by previous research into its molecular causes, researchers have developed and tested a promising gene therapy that acts directly at the origin of the disease. Initial findings show correction of molecular and physiological alterations in mouse skeletal muscle1.
"A new impetus for health biology research." This is the ambition of Inserm’s Contract of Objectives, Means and Performance signed on Friday, February 4, 2022.
Le Paris Saclay Cancer Cluster est désormais organisé sous la forme d’une association, dont l’objet et les ambitions ont été présentés ce jour dans les locaux de Gustave Roussy, en présence d’Olivier Véran, Ministre des Solidarités et de la Santé, de Frédérique Vidal, Ministre de l’Enseignement supérieur, de la Recherche et de l’Innovation et des représentants des cinq membres fondateurs : Sanofi, Gustave Roussy, l’Inserm, l’Institut Polytechnique de Paris...
Immunotherapy, a therapeutic strategy aimed at increasing the activity of the immune system in order to recognize and destroy cancer cells, has revolutionized cancer treatment over the past decade. For the first time, the scientists were able to film the lymphocytes infiltrating the walls of the HEV vessels to enter the tumors. The likelihood of recovery of patients with metastatic melanoma (skin cancer) and treated with immunotherapy is increased...
In a new study, researchers have revealed a phenomenon of programmed cell death known as "apoptosis" that would explain the loss of lymphocytes in these patients.