The CHILD-INNOVAC European research programme, coordinated by Inserm, has enabled the development of an innovative vaccine that can be administered intranasally, to combat pertussis, which has shown a resurgence in developed countries in recent years. The research consortium, headed by Camille Locht, Director of the Centre for Infection and Immunity of Lille (a joint Unit involving Inserm, CNRS, Institut Pasteur de Lille and University of Lille Nord de France),...
For the first time, scientists from the Institut Pasteur and Inserm have demonstrated the key role played by a particular molecule in intestinal infection.
Research jointly conducted by investigators at Institut Gustave Roussy, Inserm, Institut Pasteur and INRA (French National Agronomic Research Institute) has led to a rather surprising discovery on the manner in which cancer chemotherapy treatments act more effectively with the help of the intestinal flora (also known as the intestinal microbiota).
In a lymphoma model, the scientists have been able to carry out real time in vivo imaging of the cellular events activated by the treatment and resulting in the destruction of tumor cells.
A study carried out by teams from the Institut Pasteur, the Institut Cochin (Inserm, CNRS, Paris Descartes University), and the Wellcome Trust Centre for Molecular Parasitology at the University of Glasgow, may very well redefine current approaches to malaria and toxoplasmosis research in terms of treatment development.
The ANRS-12126 “Bophelo Pele” Project implemented in the township of Orange Farm in South Africa has confirmed the effectiveness of a large-scale program of voluntary medical male circumcision in prevention of heterosexually acquired HIV infection. The follow-up of over 3300 men shows a 57% to 61% reduction in the rate of new HIV infections in circumcised men compared with uncircumcised men.
Scientists at the Institut Pasteur and Inserm have identified the group of cells within the immune system that make immunotherapy treatment (therapeutic antibodies) effective. Immunotherapy is frequently used to treat breast cancer. In animal models they showed that neutrophils, the most common white blood cells in the body, are not only necessary but suffice on their own to eliminate tumor cells.
A team from INSERM Mixed Research Unit 966 “Morphogenesis and Antigenicity of HI and Hepatitis Viruses” headed by Martine Braibant and Francis Barin in Tours, has confirmed, with the support of the ANRS, that the AIDS virus has gradually adapted itself to the immune response of the human population during the course of the epidemic.
Des chercheurs ont mis en évidence chez la bactérie Escherichia coli des interactions complexes entre les voies de biosynthèse de divers facteurs de virulence : la colibactine, une génotoxine potentiellement cancérigène, et les sidérophores, molécules impliquées dans la captation du fer qui est essentiel à la survie des bactéries.
La dernière enquête ANRS VESPA2 met en lumière les progrès médicaux obtenus pour les personnes vivant avec le VIH en France et les enjeux à privilégier dans une approche renouvelée des stratégies de prise en charge pour tenir compte de l’augmentation des comorbidités et surtout des besoins sociaux de cette population. Cette enquête, réalisée par des chercheurs de l’Inserm (Unités 912, SESSTIM, Marseille et 1018, CESP Villejuif) avec le...
