Researchers from the ComPaRe cohort (Community of Patients for Research, compare.aphp.fr ), led by Prof. Philippe Ravaud, AP-HP / University of Paris / Inserm, used an original method to develop and validate the first measurement science of the severity of the disease and its impact on the lives of patients.
A long-acting antibody (LAAB) combination developed by AstraZeneca is to be evaluated in DisCoVeRy, the Inserm-coordinated European trial aimed at finding a treatment for COVID-19.
Teams from AP-HP, Sorbonne University and Inserm at the Pierre Louis Institute of Epidemiology and Public Health, coordinated by Dr Youri Yordanov and Prof. Agnès Dechartres, assessed the clinical characteristics, fate and factors associated with hospitalization or death of ambulatory patients followed using the COVIDOM device.
The severe form of Covid-19 is known to be associated with the excessive elevation of many cytokines, a condition termed “cytokine storm”. Therapy with biological agents intended to block these cytokines, for example anti-interleukin-6 or anti-interleukin-1 antibodies, was already tried, albeit with a limited success. A recent study shows that there are at least two distinct types of cytokine storms induced by SARS-CoV-2 infection that are differentially associated with...
Drawing on epidemiological field studies and the FrenchCOVID hospital cohort coordinated by Inserm, teams from the Institut Pasteur, the CNRS and the Vaccine Research Institute (VRI, Inserm/University Paris-Est Créteil) studied the antibodies induced in individuals with asymptomatic or symptomatic SARS-CoV-2 infection. The scientists demonstrated that infection induces polyfunctional antibodies.
Tout au long de la pandémie, les chercheurs et modélisateurs ont développé des méthodes pour estimer la proportion de la population ayant été infectée par le SARS-CoV-2. Ce travail d’estimation est important car il permet d’apprécier la proportion de la population qui pourrait avoir acquis une immunité (au moins partielle et de court terme) contre le SARS-CoV-2 suite à une infection naturelle.
The “Henri-Mondor” variant, never described to date, was identified within a cluster made up of three hospital professionals and the spouse of one of them. It is now actively circulating in France.
A new test to detect antibodies to SARS-CoV-2 that is reliable, inexpensive and needs no special equipment? This is the proposal of an international scientific team, of which one of the members is an Inserm researcher at the Institute of Pharmacology and Structural Biology (CNRS/Université Toulouse III - Paul Sabatier). Developed in collaboration with the University of Oxford, this serological test is based on a single reagent that causes...
Calyxis in Niort and the Inserm-Université de Bordeaux Population Health Research Center have published the findings of their study on the mental health impacts of lockdown in the journal Globalization and Health. Anxiety, depression, and self-rated mental health saw marked deteriorations in the MAVIE cohort, particularly in women, young people, elderly people, and those with less than 30 m2 of living space
Launched in October last year, the purpose of the COVIREIVAC platform coordinated by Inserm and F-CRIN in conjunction with 32 university hospitals and a network of 11 immunology laboratories is to conduct and promote first-class clinical vaccination research in France.
Les cellules cibles du SARS-CoV-2 dans les voies respiratoires produisent des molécules antivirales suite à l’infection, mais trop tardivement pour empêcher la réplication du virus.
