While it is evident that obesity, type 2 diabetes and other metabolic complications are current public health issues, their prevalence is much less clear. A team of researchers from Inra, Danone, the Paris public hospital system (AP-HP), Inserm and Sorbonne Université have recently revealed, in an in vivo preclinical study, that the metabolic disorders linked to a high fat diet are aggravated by the proliferation of Bilophila wadsworthia, a...
Day after day, the microbiota continues to yield its secrets. In a new study published in Nature Medicine, Rémy Burcelin, Inserm Research Director at the Institute of Cardiovascular and Metabolic Diseases (Inserm/UPS) along with researchers from Inserm Paris, Imperial College London, Girona Hospital and University of Rome Tor Vergata, show how certain gut bacteria cause the accumulation of fat in the liver and play a major role in fatty...
In collaboration with the team "Inflammation and stress in liver disease" of the Research Center for Inflammation (UMR 1149-Inserm-Université Paris Diderot), teams of Hepatology Services, anesthesia and resuscitation 'pathology Beaujon hospital AP-HP, Paris Diderot University and the Cochin Institute (1016 UMR Inserm-University Paris Descartes), demonstrated that a specific population of T cells, called "MAIT "played a major role in inflammation and fibrosis associated with chronic liver disease.
An estimated 75 000 people in France are unaware they are infected by hepatitis C virus. An ANRS-funded study by Sylvie Deuffic-Burban, a research associate at IAME (Infection, Antimicrobials, Modeling, Evolution) (Inserm - Université Paris Diderot - Université Paris 13), and her team shows that a universal screening strategy applied to hepatitis C is cost-effective and improves life expectancy in those infected, compared with targeted screening. These modeling results will...
Des chercheurs du CNRS, de l’Inserm et de l’Université Grenoble Alpes viennent de décrypter les mécanismes déployés par le parasite Toxoplasma gondii pour pénétrer dans les cellules de ses hôtes. À l’aide d’une imagerie quantitative à haute vitesse et haute résolution, ils ont identifié un mouvement singulier du parasite qui lui permet de fermer derrière lui la porte qu’il a créée pour rentrer dans la cellule-hôte et s’y nicher....
Inserm has long played a proactive role in scientific outreach in order to share science and biomedical research advances with the general public. And this summer 2018 will be no exception, with its host of events in which art and science will meet, in which our researchers will participate in La recherche de l’art #7 in Arles, Binôme in Avignon, and the Science in The City festival in Toulouse....
After reporting the first positive results of renal denervation in blood pressure (HBP) resistant in the journal The Lancetin 2015, the team of the Center of Excellence in Hypertension and CIC1418 APHP-INSERM led by Dr. Michel Azizi and that of the interventional radiology department led by Prof. Marc Sapoval from European Georges Pompidou Hospital, AP-HP , obtained promising new results in hypertensive patients receiving no antihypertensive therapy as part of...
Researchers from Inserm, CNRS and Université Grenoble Alpes working at the Institute for Advanced Biosciences (Joint Research Unit 1209) have analyzed the consequences of environmental exposure in utero using data collected from a cohort of 668 women. Exposure to atmospheric pollution is associated with epigenetic modifications in the placenta, presenting a risk to the fetus. These findings were published in Environment International on June 21, 2018.
Back in 2016, a team from Inserm had made a major contribution to the development of an aerosol capable of rapidly administering, into the deepest reaches of the lungs, an antidote to ricin. Ricin is highly toxic when inhaled and dreaded in the event of a bioterrorism attack.
Over 3 million people in France are currently living with cancer or have recovered from it. While the number of new cases diagnosed each year continues to increase, the advances made in diagnosis and treatment have made it possible to push back mortality. The disease remains a difficult ordeal for those affected, both physically and psychologically, and is also synonymous with social and professional disruption. In order to study the evolution of...
