Two studies, one theoretical and the other biological and clinical, conducted by Nicolas Foray, radiobiologist at the Combined Research Unit 1052 'Cancer Research Centre of Lyon' (Inserm/CNRS/Centre Léon-Bérard/Lyon I University), have just been published in the International Journal of Radiation Biology and the International Journal of Radiation Oncology. These two studies allow a better understanding of the adverse side effects of radiotherapy. They propose a new theory about the...
The researchers from Unit 1138, “Integrative Cancer Immunology,” (Inserm, Pierre and Marie Curie and Paris Descartes Universities) have analysed the tumours from 838 patients with colorectal cancer, in order to identify markers for their metastatic potential. The genomic characteristics of the cancer cells seem to have little relevance. Conversely, lymphatic vascularisation around the tumour and the intensity of the patient’s immune response appear to be crucial, and might be...
Researchers at Unit 1018 “Centre for Research in Epidemiology and Population Health” (Inserm/Paris-Sud University) at Gustave Roussy have focused on the proportion of breast cancers attributable to various risk factors. The analysis, conducted among 67,634 women in the French E3N cohort, shows that postmenopausal breast cancers are more often attributable to “behavioural” factors, such as an unhealthy diet, excess weight and alcohol consumption than “non-behavioural” factors. These data suggest...
Researchers at Inserm Unit 1194, “Montpellier Cancer Research Institute” (Inserm/University of Montpellier/Montpellier Regional Cancer Institute) have confirmed the value of a new test to identify cancer patients who will be free of sequelae following radiotherapy. This test, conducted on a blood sample taken from 500 breast cancer patients, treated in 10 centres in France, and monitored for 3 years, showed that women with a high rate of radiation-induced lymphocyte...
The vital role of the intestinal flora in successful immunotherapy has just been revealed in a study published in the journal Science. Intestinal bacteria have been identified that can improve the therapeutic response to this drug and reduce a side-effect, “inflammatory colitis,” regularly encountered with this treatment. This research implies that the efficacy of immunotherapy in oncology might in future be dictated by the composition of the patient’s intestinal flora....
Thanks to work done at Institute Curie by a team led by Fatima Mechta-Grigoriou, Inserm Research Director, it is now possible to identify, among women with aggressive ovarian cancer, those who could benefit from a promising targeted therapy.
Inserm teams led by Prof. Jean-Yves Blay and Christophe Caux in Lyon , and by Franck Tirode and Olivier Delattre in Paris have just demonstrated a new genetic variant in tumours that had not been identified until now
More than a cause of a simple infection, viruses are often involved in the development of serious diseases. Such is the case with liver cancer, which often develops in an organ that has been weakened by hepatitis B or C virus. Researchers at Inserm have just identified the role of a new virus, hitherto unsuspected, in the occurrence of a rare type of liver cancer.
Two teams of researchers from Inserm, CNRS, Centre Léon Bérard and Claude Bernard Lyon 1 University have discovered a molecule that may favour the production of these induced stem cells.
Scientists at the Institut Pasteur and Inserm have successfully increased the infiltration of immune cells into tumors, thus inducing the immune system to block tumor growth.