Hydrocortisone for critically-ill COVID-19 patients: a randomized controlled trial.

Pierre-François Dequin1,2,3, MD, PhD, Nicholas Heming4,5, MD, PhD, Ferhat Meziani6,7 , MD, PhD, Gaëtan Plantefève8, MD, Guillaume Voiriot9,10, MD, PhD, Julio Badié11, MD, Bruno François12,13,14 , MD, Cécile Aubron15,16, MD, PhD, Jean-Damien Ricard17, MD, PhD, Stephan Ehrmann1,2,3 , MD, PhD, Youenn Jouan1,2,3, MD, PhD, Antoine Guillon1,2,3, MD, PhD, Marie Leclerc18, MSc, Carine Coffre18 , MSc, Hélène Bourgouin19, PharmD, Céline Lengellé20, PharmD, Caroline Caille-Fénérol14 , MSc, Elsa Tavernier3, PhD, Sarah Zohar21, PhD, Bruno Giraudeau3,22 , PhD, Djillali Annane4,5,*, MD, PhD, Amélie Le Gouge3,* , MSc on behalf the CAPE-COVID trial group** and the CRICS-TriGGERSep network***. (*) These two authors have contributed equally.

1. Médecine Intensive-Réanimation, CHU de Tours, France 2. Inserm U1100, Centre d’Etude des Pathologies Respiratoires, Université de Tours, France 3. Inserm CIC1415, CHU de Tours, France 4. Médecine Intensive Réanimation, Hôpital Raymond Poincaré (GHU APHP Université Paris Saclay), Garches, France & RHU RECORDS & FHU SEPSIS 5. Inserm U1173, Université de Versailles SQY-Université Paris Saclay, Garches France 6. Médecine Intensive Réanimation, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, France 7. Inserm UMR 1260, Université de Strasbourg, France 8. Réanimation polyvalente, CH Victor Dupouy, Argenteuil, France 9. Médecine Intensive Réanimation, Hôpital Tenon (Assistance Publique – Hôpitaux de Paris), Paris, France 10. Sorbonne Université, Paris, France 11. Réanimation Polyvalente, Hôpital Nord Franche-Comté, Trevenans, France 12. Réanimation Polyvalente, CHU de Limoges, France 13. Inserm UMR 1092, Université de Limoges, France 14. Inserm CIC 1435, CHU de Limoges, France 15. Médecine Intensive Réanimation, CHRU de Brest, France 16. Université de Bretagne Occidentale, Brest, France 17. Université de Paris, IAME U1137, Médecine Intensive Réanimation, DMU ESPRIT, Hôpital Louis Mourier, Assistance Publique – Hôpitaux de Paris, Colombe, France 18. Délégation à la Recherche Clinique et à l’Innovation, CHU de Tours, France 19. Pharmacie à Usage Interne, CHU de Tours, France 20. Centre régional de pharmacovigilance et d’information sur le médicament, service de pharmacosurveillance, CHU de Tours, France 21. Inserm, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, France 22. Université de Tours, Université de Nantes, Inserm, SPHERE U1246, Tours, France

Journal of the American Medical Association, DOI :  doi:10.1001/jama.2020.16761

Association between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients with COVID-19: A Meta-analysis

The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group

Jonathan A C Sterne MA MSc PhD1 2, Srinivas Murthy MD MSc3, Janet V Diaz MD4, Arthur S Slutsky CM FRSC FCAHS MD5, Jesús Villar MD PhD6 7, Derek C Angus MD MPH FRCP8, Djillali Annane MD PhD9, Luciano Cesar Pontes Azevedo MD PhD10 11, Otavio Berwanger MD PhD12, Alexandre B. Cavalcanti MD PhD13, Pierre-Francois Dequin MD PhD14 15, Bin Du MD16, Jonathan Emberson PhD17 18, David Fisher MSc19, Bruno Giraudeau PhD20, Anthony C Gordon MBBS MD21, Anders Granholm MD22, Cameron Green MSc23, Richard Haynes DM FRCP17 18, Nicholas Heming MD PhD9 24, Julian P T Higgins BA PhD1 2 24, Peter Horby PhD FRCP25, Peter Jüni MD5, Martin J Landray PhD FRCP17 18 26, Amelie Le Gouge MSc20, Marie Leclerc MSc20, Wei Shen Lim BMed Sci BMBS DM FRCP27, Flávia R. Machado MD PhD28, Colin McArthur MBChB23 29, Ferhat Meziani MD PhD30 31, Morten Hylander Møller MD PhD22, Anders Perner MD PhD22, Marie Warrer Petersen MD22, Jelena Savović BPharm MSc PhD1 24, Bruno Tomazini MD10 32, Viviane C. Veiga MD PhD33, Steve Webb MBBS MPH PhD23 34 and John C Marshall MD35.

1. Population Health Sciences, Bristol Medical School, University of Bristol, United Kingdom. 2. NIHR Bristol Biomedical Research Centre, Bristol, United Kingdom. 3. Department of Pediatrics, University of British Columbia, Canada. 4. Clinical Unit, Health Emergencies Programme, World Health Organization, Geneva, Switzerland. 5. Applied Health Research Centre, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, Department of Medicine, University of Toronto, Toronto, Canada. 6. Research Unit, Hospital Universitario Dr. Negrín, Las Palmas de Gran Canaria, Spain. 7. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. 8. Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pennsylvania. 9. Department of Intensive Care, Raymond Poincaré Hospital (APHP), School of Medicine Simone Veil, University Paris Saclay -UVSQ, Paris, France. 10. Hospital Sírio-Libanês, São Paulo, Brazil. 11. Emergency Medicine Department, School of Medicine, University of São Paulo, São Paulo, Brazil. 12. Academic Research Organization, Hospital Israelita Albert Einstein, São Paulo, Brazil. 13. HCor Research Insitute, São Paulo, Brazil. 14. Médecine Intensive – Réanimation, Inserm CIC1415, CHRU de Tours, Tours, France. 15. CRICS-TriGGERSep network, Centre d’Etude des Pathologies Respiratoires, Université de Tours, Tours, France. 16. Peking Union Medical College Hospital, Beijing, China. 17. Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. 18. MRC Population Health Research Unit, University of Oxford, Oxford, United Kingdom. 19. MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, Faculty of Population Health Sciences, University College London, London, United Kingdom. 20. CHRU de Tours, Tours, France. 21. Division of Anaesthetics, Pain Medicine & Intensive Care, Imperial College London, UK. 22. Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 23. Australian and New Zealand Intensive Care Research Centre, School of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 24. NIHR Applied Research Collaboration (ARC) West, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom. 25. Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. 26. NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. 27. Respiratory Medicine Department, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. 28. Anesthesiology, Pain, and Intensive Care Department, Federal University of São Paulo, São Paulo, Brazil. 29. Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand. 30. Hôpitaux universitaires de Strasbourg, Service de Médecine Intensive Réanimation, Nouvel Hôpital Civil, Strasbourg, France. 31. INSERM UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Strasbourg, France. 32. Department of Surgery, School of Medicine, University of São Paulo, São Paulo, Brazil. 33. BP – A Beneficência Portuguesa de São Paulo, São Paulo, Brazil. 34. St John of God Healthcare, Subiaco, Western Australia, Australia. 35. Li Ka Shing Knowledge Institute, St. Michael’s Hospital, University of Toronto, Toronto, Canada.

Journal of the American Medical Association, DOI : 10.100/jama.2020.17023