Category Archives: Circulation, metabolism, nutrition

Osteoarthritis and metabolic disease: a “joint” therapeutic target?

Pour la première fois, des chercheurs du laboratoire de recherche « Ingénierie moléculaire et physiopathologie articulaire » (Cnrs/Université de Lorraine) et du laboratoire « Défaillances cardiovasculaires aiguë et chronique » (Inserm/Université de Lorraine) à Nancy, ont décrit le développement spontané de ce type d’arthropathie dégénérative dans un modèle murin de SMet.

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Rare genetic obesity: promising results from a clinical trial

POMC (proopiomelanocortin) deficiency obesity is an orphan disease which has been described in 50 patients to date, although it is estimated to affect 100–500 people worldwide. Although there is currently no specific treatment, a publication in NEJM reports promising results from a phase 2 clinical trial that led to considerable weight loss in female patients.

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Red blood cell fragments attack blood vessels

Vaisseaux sanguins et globules rouges

A new study published in the journal Blood shows that red blood cells can turn against blood vessels by releasing aggressive fragments that contribute to the development of cardiovascular disease.

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A vaccine against house dust mite allergy?

In this work, carried out by researchers from Inserm and the French National Institute for Agricultural Research (INRA), in collaboration with researchers from the University of Vienna, Austria, a fragment of Der p 2 was generated by genetic engineering, and its protective effect against house dust mite asthma was then tested in a mouse model of asthma.

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Fatty plaques in the arteries associated with dementia in older subjects

Dans un travail publié en ligne dans la revue Alzheimer’s & Dementia, les chercheurs de l’Inserm, se sont intéressés aux relations entre l’athérosclérose et le risque de démence chez le sujet âgé.

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Diabetes: fasting in the wrong place at the wrong time

Roméo Ricci’s team at the Institute of Genetics and Molecular and Cellular Biology has shown that, during fasting, the pancreatic beta cells do not compensate for nutrient deficiencies by the “classic” autophagy mechanism but by breaking down insulin secretory granules

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Using “good cholesterol” as a therapeutic vector for treating the lungs

In a new study published in The American Journal of Respiratory Cell and Molecular Biology, Olivier Meilhac’s team (Inserm Unit 1148, the “Laboratory for Vascular Translational Science,” in collaboration with Inserm Unit 1152, “Physiopathology and Epidemiology of Respiratory Diseases”) addressed the transport capability of HDLs (high density lipoproteins, commonly known as “good cholesterol”)

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The satiety mechanism described and restored in mice

Leptin is a hormone secreted by adipose cells, sending the satiety signal to the brain. Sometimes, certain overweight or obese individuals develop resistance to this hormone, which is no longer able to deliver its message.

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Better dosing of “good cholesterol” for greater efficacy

In reality, the cholesterol levels are the result of a balance in the human body between “good” (HDL) cholesterol and “bad” (LDL) cholesterol.

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Breathe…inhale…run

Onze athlètes non-asthmatiques présentant de hautes capacités d’endurance ont été recrutés pour comparer en double-aveugle deux niveaux de dose de salbutamol (200 et 800 µg) administrés par inhalation contre un placebo avant un test d’effort des muscles de la jambe.

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