When the male genome carried in the spermatozoid leaves the male body to reach the egg, it undergoes numerous transformations. A team led by Saadi Khochbin in Mixed Research Unit 823 at the Institut Albert Bonniot Research Centre (Inserm/Joseph Fourier University) in Grenoble has described the molecular mechanisms that enable the transmission of the male genome to the egg.
Researchers at IGS, the genomic and structural information laboratory (CNRS/Aix-Marseille University), working in association with the large-scale biology laboratory (CEA/Inserm/Grenoble Alpes University) have just discovered two giant viruses which, in terms of number of genes, are comparable to certain eukaryotes, microorganisms with nucleated cells.
Une nouvelle cible pharmacologique permettant d'améliorer le fonctionnement du muscle vient d'être découverte chez la souris par l'équipe d'Hélène Duez, chargée de recherche à l'Inserm dans l'unité 1011 "Récepteurs nucléaires, maladies cardiovasculaires et diabète" (Inserm/Université Lille 2 droit et santé/Institut Pasteur de Lille) dirigée par Bart Staels.
Des chercheurs ont mis en évidence chez la bactérie Escherichia coli des interactions complexes entre les voies de biosynthèse de divers facteurs de virulence : la colibactine, une génotoxine potentiellement cancérigène, et les sidérophores, molécules impliquées dans la captation du fer qui est essentiel à la survie des bactéries.
Research conducted by Cyrille Delpierre (INSERM Unit 1027 “Epidemiology and Public Health Analyses: Risks, Chronic Illness and Handicaps”) in collaboration with the French Cancer Registers Network assessed the proportion of patients potentially suffering from prostate cancer and currently over-diagnosed or over-treated in France. According to a study performed on 1840 patients, current over-treatment involves a considerable number of patients being treated for a cancerous tumour in what is known...
In the Web 2.0 and “Quantified Self” era, scientists are working to improve traditional data collection methods (face-to-face interviews, telephone interviews or paper questionnaires), which are expensive and time-consuming for study participants. Indeed, recruitment, monitoring and data collection tools need to be adapted to fit the habits of the younger generation. The Internet and smartphones offer numerous options for collecting data on participants’ lifestyle, environment and health, in a...
La dernière enquête ANRS VESPA2 met en lumière les progrès médicaux obtenus pour les personnes vivant avec le VIH en France et les enjeux à privilégier dans une approche renouvelée des stratégies de prise en charge pour tenir compte de l’augmentation des comorbidités et surtout des besoins sociaux de cette population. Cette enquête, réalisée par des chercheurs de l’Inserm (Unités 912, SESSTIM, Marseille et 1018, CESP Villejuif) avec le...
Patrick Collombat, Inserm Research Director and head of the Avenir team at the Institut de Biologie Valrose in Nice, has published new results concerning Type I diabetes. Researchers show that, in mice, the pancreas contains cells capable of being converted into insulin-producing β cells, something that can be done at any age.
The Inserm researchers at unit 1018, "The Epidemiology and Public Health Research Centre", working in collaboration with researchers from England and Finland have demonstrated that it is essential to be vigilant about this and to take it very seriously when people say that they are stressed, particularly if they believe that stress is affecting their health.
Certain food contaminants are suspected of triggering metabolic disorders, or of worsening them, particularly when they accompany a high-fat diet. In order to get a better understanding of these effects, researchers from the Inserm cardiovascular, metabolism, diabetology and nutrition unit introduced a "cocktail" of contaminants mixed with low doses of dioxin, PCB, bisphenol A and phtalates into the feeding of mice that had already been rendered obese by...