Scientists from the Institut Pasteur (a partner research organization of Université Paris Cité), Inserm and the CNRS have discovered that hypothalamic neurons in an animal model directly detect variations in bacterial activity and adapt appetite and body temperature accordingly. These findings demonstrate that a direct dialog occurs between the gut microbiota and the brain, a discovery that could lead to new therapeutic approaches for tackling metabolic disorders such as...
In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, researchers describe the mechanisms that modify the structure of T lymphocytes and hinder their migration towards the tumors to be destroyed. This discovery provides new perspectives on the migration of immune cells, a key process...
Dans une nouvelle étude, des scientifiques ont identifié, à partir des données de près de 26 000 volontaires de la cohorte Constances, quels symptômes persistants sont le plus fréquemment rapportés par les personnes ayant été infectées par le SARS-CoV-2 comparé au reste de la population. Il s’agit principalement de la perte de goût ou d’odorat, de gêne respiratoire ou de fatigue.
Rémi Quirion, Quebec’s Chief Scientist, and Dr. Gilles Bloch, Chairman and Chief Executive Officer of the French National Institute of Health and Medical Research (Inserm), are pleased to announce the signing of a new joint Declaration of Intent between the Quebec Health Research Fund and Inserm. Covering the next four years, this declaration renews an institutional partnership spanning over half a century.
A very small percentage of people with HIV-1, known as "post-treatment controllers" (PTCs), are able to control their infection after interrupting all antiretroviral therapy. Understanding the fundamental mechanisms that govern their immune response is essential in order to develop HIV-1 vaccines, novel therapeutic strategies to achieve remission, or both. A recent study investigated the humoral immune response – also known as antibody-mediated immunity – in some PTCs in whom...
Researchers have studied the impact of individual sociodemographic, behavioral and health factors on the practice of daily physical activity in later life, using data from 3,896 participants of the Whitehall II cohort. This research highlights the complexity of individual barriers to an active lifestyle among older adults and suggests that this complexity should be better taken into account when redefining public health policies.
Researchers have identified 75 regions of the genome that are associated with Alzheimer's disease. Forty-two of these regions are novel, meaning that they have never before been implicated in the disease. The findings bring new knowledge of the biological mechanisms at play and open up new avenues for treatment and diagnosis.
In order to evaluate the risk of cancer linked to them, researchers analyzed data relating to the health of 102,865 French adults participating in the NutriNet-Santé cohort study and their consumption of artificial sweeteners. The results of these statistical analyses suggest a link between the consumption of artificial sweeteners and an increased risk of cancer.
L’ensemble des membres fondateurs s’interroge sur la tenue d’un tel évènement au sein d’un Institut hospitalo-universitaire. L’intitulé et la nature des participants et des associations partenaires ne laissent aucun doute sur les objectifs. Par conséquent, les membres fondateurs demandent la délocalisation de cette conférence.
Studies have shown that the risk of ischemic stroke is increased by the use of antipsychotics: medications with antidopaminergic properties that are commonly prescribed in psychiatry. Researchers evaluated the ischemic stroke risk associated with exposure to other antidopaminergic medications—antiemetics, which are very commonly used in the symptomatic treatment of nausea and vomiting. The findings of this study, show a link between the use of these medications and the risk...