A new strategy for emergency anticoagulant treatment for patients with acute myocardial infarction has been put in place by a team led by Philippe-Gabriel Steg at Inserm Unit 698 (Haemostasis, Bioengineering, Immunopathology and Cardiovascular Remodelling), at Hôpital Bichat, AP-HP, Université Paris Diderot).
Despite their efforts, many morbidly obese people continue to consume too much food (hyperphagia) compared to their reserves and their needs. And yet, the hunger hormone, called ghrelin, is most frequently found at a normal or even lower level in these patients. The Inserm Unit 1073 team "Nutrition, inflammation and dysfunction of the gut-brain axis" (Inserm/University of Rouen) has just explained this mechanism causing this paradoxical hyperphagia. Certain antibodies...
Inserm researcher Elvire Gouze, and her associates from the Mediterranean Centre for Molecular Medicine in Nice (Inserm Unit 106), have succeeded in restoring bone growth in mice suffering from this developmental pathology.
By means of virtual screening and experiments on mice and human cells in culture, the scientists were able to screen 200,000 compounds and selected two that allowed the causal mutated protein in cystic fibrosis to express itself and fulfill its function.
The European Union commits funds to the FIBRO-TARGETS research consortium
Menée par le Pr Philippe Gabriel Steg, de l'hôpital Bichat, (AP-HP) et l’équipe de recherche affiliée au Département Hospitalo-Universitaire FIRE, à l’Université Paris-Diderot et à l'Unité Inserm U-698, l’étude a porté sur plus de 24 000 patients traités par angioplastie et sur un nouveau traitement antiplaquettaire injectable inhibant la formation des caillots de plaquettes, le cangrelor. Les chercheurs ont analysé la totalité des résultats obtenus avec ce nouveau traitement...
They observed that these individuals were deficient in intestinal bacteria (in both quantity and diversity) and were at greater risk of developing cardio-metabolic diseases.
A research team from Toulouse has just elucidated the mechanisms behind the differences in iron absorption between men and women. The team used mice to demonstrate how the action of testosterone can be “countered” with a drug already used in the treatment of some bronchial cancers.
Une nouvelle cible pharmacologique permettant d'améliorer le fonctionnement du muscle vient d'être découverte chez la souris par l'équipe d'Hélène Duez, chargée de recherche à l'Inserm dans l'unité 1011 "Récepteurs nucléaires, maladies cardiovasculaires et diabète" (Inserm/Université Lille 2 droit et santé/Institut Pasteur de Lille) dirigée par Bart Staels.
Patrick Collombat, Inserm Research Director and head of the Avenir team at the Institut de Biologie Valrose in Nice, has published new results concerning Type I diabetes. Researchers show that, in mice, the pancreas contains cells capable of being converted into insulin-producing β cells, something that can be done at any age.