Teams from AP-HP, INRA, Gustave Roussy and Inserm can demonstrate the role of microbiota in the response of immunotherapy for cancer. They show that in man, the composition of gut microbiota can help to identify the patients who will respond favourably or not to treatment for melanoma, with Ipilimumab. This clinical study, carried out in 26 patients, suggests that a modification of the composition of gut microbiota could improve...
Inserm and the Coalition for Epidemic Preparedness Innovations (CEPI) are holding a large conference entitled "Vaccines Against Emerging Infections – a Global Insurance" on 21 and 22 February 2017. It is especially aimed at emphasising the urgent need for action and the potential for developing vaccines in the area of world epidemic crises. François Hollande, President of France, attended this conference today, along with Yves Levy, Chairman and CEO...
Scientists estimate that approximately 95 percent of adults around the world are infected with the Epstein-Barr virus. In rare cases, an infection with this virus causes cancer. Scientists at the German Cancer Research Center (DKFZ), at the German Center for Infection Research (DZIF), and at the French National Institute of Health and Medical Research (Inserm) have now discovered that a component of the Epstein-Barr virus infectious particle promotes carcinogenesis....
In November 2014, Inserm organised medical follow-up of people who survived infection by the Ebola virus. 802 individuals (adults and children) were included in the PostEbogui cohort. Results of follow-up show that on average one year after their initial period in hospital, 3 in 4 survivors still report health problems.
L'équipe d'Ali Amara, directeur de recherche Inserm, décrit, dans un article publié dans Cell Reports, les mécanismes permettant au virus Zika d'infecter les cellules du système nerveux.
Scientists have finally observed the hepatitis C virus (or HCV) using an electron microscope. This is the first time since the virus became known in 1990. Inserm researchers at Tours (Inserm unit 966, “HIV and Hepatitis Viruses: Morphogenesis and Antigenicity”) have taken other scientists by surprise, including an American team believed to have accomplished this feat in 2013. The latter had in fact misunderstood the nature of the particles...
An international research team involving Inserm and the National Institutes of Health (NIH) has just published the results of the PREVAIL study on treatment for the Ebola virus. While not definitive, the results show that ZMapp may benefit patients with the Ebola virus disease. These results are published in The New England Journal of Medicine.
Recent work has shown that Zika virus persists in semen for up to 6 months after infection[1]. In a correspondence published in The Lancet Infectious Diseases, the researchers, in addition to confirming its long persistence in semen (in this case for more than 130 days, i.e., over 4 months), reveal the presence of the virus even within spermatozoa. This work results from collaboration between researchers from Inserm, CNRS, and...
The team “Physiopathology and therapeutics of chronic viral hepatitis and related cancers” of the Mondor Institute of Biomedical Research (Inserm/UPEC), located on the premises of Henri Mondor Hospital AP-HP, in collaboration with the researchers of the Centre for Structural Biochemistry (CNRS/Inserm/Montpellier University), with the support of ANRS, has created a whole new family of molecules that inhibit cyclophilins – proteins indispensable to cell metabolism – and have strong therapeutic...
A disruptive element such as a change in diet, and the whole intestinal flora becomes disrupted, with possible repercussions for health. An international research study conducted by the Molecular Microbial Pathogenesis Unit (Institut Pasteur/Inserm), directed by Philippe Sansonetti, has just demonstrated, in mice, the direct influence of a diet too high in fat on the intestinal flora and its environment. In response to this new diet, the bacterial communities...