Teams of researchers conducted a clinical gene therapy study consisting of transplanting in the patient's own genetically modified hematopoietic stem cells. This phase I/II clinical trial was carried out in patients with sickle cell disease or transfusion-dependent beta thalassemia, common genetic diseases that affect red blood cells.
Researchers have carried out work on treatment by gene therapy consisting of transplanting the patient's own genetically modified hematopoietic stem cells as part of a phase I/II clinical trial in 8 patients with Wiskott-Aldrich syndrome (WAS).
In collaboration with a Canadian team, scientists from Inserm and Université de Tours, at Unit 1253 Imaging & Brain1, have shown in post-mortem brain samples that victims of child abuse present specific brain characteristics. This research suggests that abuse could cause lasting changes to the developmental trajectories of certain brain regions with potential effects on psychological health.
A team of scientists led by Inserm Research Director Basile Chaix at the Pierre Louis Institute of Epidemiology and Public Health (Inserm/Sorbonne Université) studied the impact of these parameters on exposure to black carbon, an air pollutant produced by road traffic.
Reducing fine particle mortality in a conurbation by two-thirds could be achieved at a cost that is much lower than the value of the societal and economic benefits obtained, according to a study by a multidisciplinary team from CNRS, INSERM, INRAE, Grenoble Alpes University (UGA) and Atmo Auvergne-Rhône-Alpes. The study identifies specific public policies that could achieve health objectives set by local decision makers, as well as their expected...
Multiple myeloma is a cancer of the bone marrow, with a life expectancy of less than 5 years post-diagnosis. While studying a neglected tropical disease, Buruli ulcer, researchers from the Institut Pasteur and Inserm discovered a novel therapeutic target for multiple myeloma that could allow to bypass this resistance.
France has one of the world’s highest levels of cannabis use, with around 40% of 17-year-olds reported to have used it in the previous year. New findings indicate that those having used cannabis are more likely to experience a period of unemployment later, especially if they were under 16 when they started.
Scientists had previously shown in mice that the presence of emulsifiers in many processed foods could promote intestinal inflammation. In a new study, the same team has shown in healthy human volunteers that carboxymethylcellulose (CMC), a widely used food emulsifier, affects the intestinal environment by altering the composition of the microbiota.
What if a few minutes of sleep could trigger creativity? This is what suggests a study by researchers from Inserm and Sorbonne Université at the Brain Institute and the department of sleep medicine at Pitié-Salpêtrière Hospital AP-HP.
Why are children less susceptible than adults to critical forms of COVID-19? A number of interesting avenues are emerging, notably suggesting differences in immune response following SARS-CoV-2 infection. In a new study, researchers have shown that the interferon response, which is part of the innate immune response, differs according to the age of the patient.
