Understanding the three-dimensional structure of DNA and RNA and how they interact with other molecules is necessary for the advancement of biomedical research and drug development. A team led by Inserm researcher Valérie Gabelica at the Nucleic acids: natural and artificial regulation laboratory (ARNA, Inserm/CNRS/Université de Bordeaux)[1] has developed an innovative method pairing mass spectrometry with circularly polarized light, enabling better characterization of these different molecular interactions.
Inserm, with the support of the REACTing network, Public Health France, the country’s university hospitals, and the French College of Teachers in General Practice, is launching COVIREIVAC. This platform for the clinical evaluation of COVID-19 vaccine candidates will make it possible to test them rigorously and obtain robust data on their safety and ability to induce an immune response (immunogenicity).
Huntington's disease is a genetic neurological condition that usually manifests in adulthood. Teams of researchers and clinicians from Inserm, Université Grenoble Alpes, Sorbonne Université, CNRS and AP-HP at the Grenoble Institute of Neuroscience and the Brain Institute, have discovered abnormalities in the brains of human embryos that carry the mutation responsible for Huntington's disease.
In a study published in Science on July 13, teams from AP-HP, Inserm, Université of Paris, Institut Pasteur and Institut Imagine describe a unique and unexpected immunological phenotype in severe and critical patients, consisting of a severely impaired response of interferon (IFN) type I, associated with a persistent blood viral load and an excessive inflammatory response.
Hypnosis fascinates by its esoteric, almost magical side. One thinks of the hypnotist who puts crowds to sleep... But there's a whole other field in which hypnosis is being emulated, that of health. Listen only to our voice... Detox Channel cuts off false information.
Cannabis use can lead to behavioral changes, including reduced social interactions in some individuals. To better understand the phenomenon, Inserm researcher Giovanni Marsicano and his team from NeuroCenter Magendie (Inserm/Université de Bordeaux), in collaboration with Juan Bolaños' team from the University of Salamanca, have identified for the first time in mice the cerebral mechanisms underlying the relationship between cannabis and reduced sociability.
In France, the strategy for preventing iron deficiency in young children is partly based on the recommendation to use iron-fortified infant formula – including growing-up milk – when breastfeeding is discontinued. The researchers found that the consumption of iron-fortified infant formula very significantly reduced the risk of iron deficiency and met the recommended daily nutrition requirements for nearly half of the children.
A study, aimed at identifying the risk factors for the severity of COVID-19 in patients with multiple sclerosis in France, was carried out by teams from the neurology department of the Pitié-Salpêtrière hospital AP -HP, from the Brain Institute (Inserm / CNRS / Sorbonne University) at the Pitié-Salpêtrière hospital AP-HP, from Sorbonne University and the neurology service of the Strasbourg CHU.
Les deux bras testant la combinaison lopinavir/ritonavir avec ou sans interféron bêta sont arrêtés dans les essais cliniques Solidarity et Discovery. Compte tenu de la nature adaptative des deux essais, une réflexion est en cours sur l'évolution du protocole. Des publications dans des journaux internationaux à comité de lecture sont en préparation concernant tant l'évaluation de l'hydroxychloroquine que du lopinavir/ritonavir.
Depuis plusieurs années, un débat portant sur l’efficacité contre le paludisme de divers produits non pharmaceutiques à base d’Artemisia agite la communauté scientifique. Il fait son retour avec l'épidémie de Covid-19.
