Several months after infection with SARS-CoV-2, some patients still have symptoms: a phenomenon commonly referred to as "long COVID". Teams from Inserm and Université Paris Cité, in collaboration with the University of Minho in Braga (Portugal), have shown that this could be explained biologically by abnormalities of the immune system associated with the persistence of the virus in the mucous membranes.
For the first time, researchers from Institut Curie, the CNRS and Inserm have uncovered a previously unknown chain of biochemical reactions. This chain involves copper and leads to metabolic and epigenetic alterations that activate inflammation and tumorigenesis. But there is more; the research team developed a “drug prototype” capable of mitigating both the mechanisms of inflammation and the processes potentially involved in metastatic spread.
Restaurer la vision grâce à une thérapie associant génétique et ultrasons ? Tel est l’objectif poursuivi par une équipe internationale dirigée par les directeurs de recherche Inserm Mickael Tanter et Serge Picaud, associant respectivement le laboratoire Physique pour la médecine (ESPCI Paris/PSL Université/Inserm/CNRS) et l’Institut de la vision (Sorbonne Université/Inserm/CNRS) à Paris en partenariat avec l’Institut d'ophtalmologie moléculaire et clinique de Bâle. Dans une nouvelle étude, ils ont apporté la...
Multiple sclerosis (MS), an autoimmune disease for which there is no cure as yet, affects three women for every one man. Faced with this observation, scientists are studying the role of the sex hormones in order to better understand the differences between men and women in relation to the disease and its progression.
A large part of the population has developed immunity against SARS-CoV-2 following infection, vaccination – or both. In addition, some infected patients enjoy "hybrid" immunity when they are vaccinated following their infectious episode.
In crowded places, such as airports and train stations, social distancing is difficult to maintain and the risk of infectious disease transmission is increased. In order to reduce this risk, it is essential that we improve our understanding of the dynamics of disease transmission within such places and the effective mitigation measures that can be implemented at low cost.
Exposure to extreme temperatures from the fetal stage could impact health. This is what suggests a study by researchers from Inserm, Université Grenoble Alpes and CNRS, based on the SEPAGES cohort, intended to study the impact of various environmental factors on the health of pregnant women and their children.
Highly infectious and potentially life-threatening in infants, whooping cough, caused by the bacterium Bordetella pertussis, continues to circulate to a large extent throughout the world. Although the vaccines currently used protect against the onset of symptoms, they have limited durability and cannot prevent bacterial infection resulting in transmission between individuals.