La propagation des agrégats de la protéine Tau dans le cerveau contribue à la progression de la maladie d’Alzheimer. Des chercheurs du Laboratoire des maladies neurodégénératives : mécanismes, thérapies, imagerie (CNRS/CEA/Université Paris-Sud, MIRCen), en collaboration avec l’Ecole normale supérieure, Sorbonne Université et l’Inserm, viennent d’identifier les cibles de ces agrégats. Publiés dans EMBO Journal le 10 janvier 2019, ces travaux permettront la conception d’outils capables de bloquer ces éléments clés...
Appointed by the French Council of Ministers on November 26, 2018, Gilles Bloch took up his post as Chairman and Chief Executive Officer of Inserm on January 2, 2019.
What happens inside our brains when we sleep? To answer this question, French researchers have, for the first time, filmed the entire brain in sleeping rats, thanks to innovative ultrasound imaging technology. They were thus able to closely observe brain function in rodents, particularly during the REM sleep phase. These results were obtained in shared Inserm, ESPCI Paris, CNRS, and Sorbonne University laboratories. Published in Nature Communications, these findings...
Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. In fact, they found how a mutation, causes dysfunction in a protein which inhibits neuronal electrical activity, induces migraines. These results, published in Neuron on December 17, 2018, open a new path for the development of anti-migraine medicines.
A diet based on MON 810 or NK603 transgenic maize does not affect the health or metabolism of rats, under the conditions of the GMO 90+1 project1. This unprecedented study performed by a research consortium led by Inra brought together a number of partners2, including Inserm. The research was performed as part of the Risk’OGM program funded by the French Ministry of Ecological and Inclusive Transition. For six months,...
Restoring the action of insulin is one of the keys to fighting type 2 diabetes. Researchers from Inserm led by Dominique Langin at the Institute of Cardiovascular and Metabolic Diseases (Inserm/Université de Toulouse) are developing a therapeutic strategy that uses the properties of an enzyme (hormone-sensitive lipase) which, when stimulating fatty-acid synthesis in the fat cells, has a beneficial effect on insulin action. This research has been published in...
This year’s Inserm Prize ceremony will take place on Tuesday December 11, 2018, at the Collège de France in celebration of nine researchers and engineers whose achievements have helped raise the level of scientific excellence at the Institute, in the service of science for health. "By honoring its talents, Inserm wishes to showcase the diversity and richness of the biomedical research professions, and the creativity and passion of the...
Gilles Bloch has been appointed Chairman and Chief Executive Officer of the French National Institute of Health and Medical Research (Inserm) by the Council of Ministers.
As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology...
Asymmetry plays a major role in biology at every scale: think of DNA spirals, the fact that the human heart is positioned on the left, our preference to use our left or right hand … A team from the Institute of biology Valrose (CNRS/Inserm/Université Côte d’Azur), in collaboration with colleagues from the University of Pennsylvania, has shown how a single protein induces a spiral motion in another molecule. Through...