Inserm Newsroom - Press room of the French national institute of health and medical research

Cirrhosis: a predictor of mortality accurate prognosis

A trial sponsored by AP-HP and conducted by teams of Beaujon Hospital, AP-HP, Inserm and Université Paris Diderot was set up to establish an indicator that reflects the severity of liver disease in patients with cirrhosis. Coordinated by Professor Pierre-Emmanuel Rautou and Dr. Audrey Payancé the Hepatology Service of Beaujon Hospital, AP-HP, this study establishes that measurement microvesicles rate from liver and circulating in the blood greatly improves prediction of 6-month mortality of patients with cirrhosis.

This indicator would better choose treatments offer in patients with cirrhosis. These results, published in the journal Hepatology , also opening a reflection on the value of strategies to reduce the rates of these microvesicles in the blood of patients with cirrhosis.

World Asthma Day

Tuesday May 1 is World Asthma Day – a day to educate and raise public awareness to improve the diagnosis and treatment of asthma.

World Asthma Day

Tuesday May 1 is World Asthma Day – a day to educate and raise public awareness to improve the diagnosis and treatment of asthma. Asthma is a respiratory disease that can be brought on by pollution, various allergies or genetic predisposition. It affects 9% of children, and those under the age of 15 account for […]

Discovery of a future therapy for hemoglobinopathies

With the genome editing CRISPR-case.9 technique, researchers at INSERM, the hospital Necker Children-AP-HP, and Université Paris Descartes in the Institute Imagine managed to reactivate a gene that may improve the appearance of red blood cells of patients with hemoglobinopathies such as sickle cell anemia and beta-thalassemia. The teams Annarita Miccio, Inserm researcher, Prof. Marina Cavazzana AP-HP and Isabelle André-Schmutz, Inserm researcher show this new avenue of research and treatment of β -hémoglobinopathies in the journal Blood .

Apparent age of the elderly : a diagnostic tool for primary care physicians?

To estimate the health of their elderly patients, healthcare professionals have various clinical tools at their disposal: geriatric assessment scales, health questionnaires and frailty scores. However, although these tests are appropriate to a medical context, they are more difficult for primary care physicians (PCPs) to implement because they require time and equipment that they do […]

Wednesday, April 25, 2018: World Malaria Day

Caused by a parasite of the genus Plasmodium, malaria is transmitted to humans through bites from the female Anopheles mosquito. It can also be transmitted via blood transfusion or from mother to child at the end of pregnancy. [1] In 2016, the number of deaths caused by malaria was estimated at 445,000. Half of the […]

New gene therapy success in beta thalassemia: 22 patients treated in France, United States, Thailand and Australia

In an article in the New England Journal of Medicine published on April 19, the intermediate results of a clinical trial (HGB-205) led by Pr. Marina Cavazzana and her teams at the Necker-Enfants malades hospital AP-HP in collaboration with the Imagine Institute (AP-HP/Inserm/Paris Descartes University) as well as those of an international multicenter trial (HGB-204) conducted in the United States, Thailand and Australia, show that gene therapy is effective in improving the state of health or curing patients with beta thalassemia. These two clinical trials have used the same therapeutic vector “LentiGlobin”, developed at Harvard University in Boston and at the CEA in Fontenay-aux-Roses by Pr. Philippe Leboulch, in collaboration with the American company bluebird bio, for which he is the founder.

Preserving Kidneys to Avoid Dialysis

How can we preserve renal function in people with a chronic kidney disease? Can dialysis be avoided or delayed? To answer these questions and many others, Inserm and Université Paris-Sud have set up the CKD-REIN1 cohort study, led by Bénédicte Stengel. Today it has produced its first results. According to the study, conducted with more than 3,000 patients, several priorities may improve the management of kidney disease. These priorities include improving blood pressure monitoring, providing more nutritional advice, and raising awareness among patients and health care professionals about the risk of medicine overdose.

Immunization Week 2018

The thirteenth annual World Immunization Week will take place from April 23 to 29, 2018. The campaign, created by the World Health Organization (WHO), undertakes to raise awareness about the stakes of vaccine protection.

Immunization Week 2018

The thirteenth annual World Immunization Week will take place from April 23 to 29, 2018. The campaign, created by the World Health Organization (WHO), undertakes to raise awareness about the stakes of vaccine protection. This year, WHO is focusing on the importance of immunizing every child to “prevent the relevant diseases and protect their lives.” […]