Known to be a possible cause of certain chronic diseases, vitamin D deficiency is also believed to lead to a high risk of developing Alzheimer's disease, especially where the diet is also poor in 'good fats' and antioxidant carotenoids. This is what two studies led by Catherine Féart and Cécilia Samieri, researchers at Inserm unit 1219 Bordeaux Population Health (BPH) (Inserm/ Bordeaux University), have shown. The research was published...
The hypothesis that cannabis consumption has a direct effect on concentration, motivation, and the academic success of young people in the long-term is supported by neuroscience research data which demonstrates specific lesions in teenage users. Maria Melchior, Inserm Research Director (Pierre Louis Institute of Epidemiology and Public Health, Inserm-Université Pierre et Marie Curie, Paris), and her French and North American colleagues wished to study the possible existence of a...
A team of researchers from Prof. Robert Barouki's Inserm unit (Inserm Unit 1124/Université Paris Descartes), led by Prof. Xavier Coumoul, has recently shown that the Seveso dioxin, an organic pollutant found in our food and in the atmosphere, causes liver damage in mice fed a high-fat diet. This effect is related to its action on a signaling pathway also activated by diesel and tobacco particles. The results were published...
Teams from AP-HP, INRA, Gustave Roussy and Inserm can demonstrate the role of microbiota in the response of immunotherapy for cancer. They show that in man, the composition of gut microbiota can help to identify the patients who will respond favourably or not to treatment for melanoma, with Ipilimumab. This clinical study, carried out in 26 patients, suggests that a modification of the composition of gut microbiota could improve...
The French National Institute of Health and Medical Research (Inserm), the US National Institutes of Health (NIH) and the London School of Hygiene & Tropical Medicine (LSHTM), in collaboration with health authorities in Guinea and Liberia, are launching a large clinical trial of candidate Ebola vaccines under the aegis of the PREVAC international consortium (Partnership for Research on Ebola VACcination).
Le rôle des facteurs nutritionnels (alimentation et activité physique) dans le développement du surpoids et de l’obésité et dans la survenue de nombreuses maladies chroniques telles que les cancers, les maladies cardiovasculaires, le diabète et l’arthrose est à ce jour scientifiquement bien établi. Ces maladies constituent la première cause de mortalité à l’échelle de la planète et le nombre de patients concernés ne cesse d’augmenter.
A new study conducted by Inserm researchers at Irset (Institute of Research in Environmental and Occupational Health)[1] shows that ibuprofen is liable to cause disruptions in the hormone system in the human foetal testis, with possible implications for the development of the male urogenital tract. This drug suppresses the production of various testicular hormones, including testosterone, which controls the primary and secondary sex characteristics and the descent of the...
A team led by Prof. Marina Cavazzana, working at Necker Hospital for Sick Children, AP-HP, and the Imagine Institute (AP-HP/Inserm/Paris Descartes University) performed gene therapy on a 13-year-old patient with severe sickle cell anaemia in October 2014 as part of a phase I/II clinical trial. Conducted in collaboration with Prof. Philippe Leboulch (CEA/Faculties of Medicine at Paris-Sud and Harvard Universities), who developed the vector used, and supervised the preclinical...
Une consommation élevée de charcuterie (au moins 4 fois par semaine) est associée à une aggravation des symptômes de l'asthme au cours du temps.
A new home-based therapeutic approach targeting dementia patients, “occupational therapy,” can slow their loss of autonomy and reduce behaviour problems. These results come from a new study published by Inserm researchers (Unit 1219 “Institute of Public Health, Epidemiology and Development” [ISPED]) in the Journal of Alzheimer’s Disease.
Nearly one in two French people over 30 years of age are overweight. This is what the first results from the Constances cohort has revealed. Now supported by Inserm and the French national social security organisation for salaries workers (Cnamts), Constances collates health data on more than 110,000 French people. With ultimately 200,000 people monitored, Constances will provide varied indicators of health in the population, such as the influence...
