How can we limit age-related decrease in muscle capacity (sarcopenia), which is a major cause of loss of autonomy in the elderly? Researchers from Inserm, Université Toulouse III – Paul Sabatier and the Gérontopôle of Toulouse University Hospital might have found, within the muscles themselves, a formidable ally in fighting this disease: apelin. This hormone, whose production decreases with age, is secreted during physical activity and improves muscle capacity....
Chronic malnutrition, usually associated with an inflammation of the small intestine, affects one in every four children under the age of five. It is the leading cause of child mortality in low-income countries and is also responsible for severe stunting. The Afribiota project, led by the Institut Pasteur in Paris, the Institut Pasteur in Madagascar and the Institut Pasteur in Bangui, in collaboration with the University of British Colombia,...
While it is evident that obesity, type 2 diabetes and other metabolic complications are current public health issues, their prevalence is much less clear. A team of researchers from Inra, Danone, the Paris public hospital system (AP-HP), Inserm and Sorbonne Université have recently revealed, in an in vivo preclinical study, that the metabolic disorders linked to a high fat diet are aggravated by the proliferation of Bilophila wadsworthia, a...
Day after day, the microbiota continues to yield its secrets. In a new study published in Nature Medicine, Rémy Burcelin, Inserm Research Director at the Institute of Cardiovascular and Metabolic Diseases (Inserm/UPS) along with researchers from Inserm Paris, Imperial College London, Girona Hospital and University of Rome Tor Vergata, show how certain gut bacteria cause the accumulation of fat in the liver and play a major role in fatty...
In collaboration with the team "Inflammation and stress in liver disease" of the Research Center for Inflammation (UMR 1149-Inserm-Université Paris Diderot), teams of Hepatology Services, anesthesia and resuscitation 'pathology Beaujon hospital AP-HP, Paris Diderot University and the Cochin Institute (1016 UMR Inserm-University Paris Descartes), demonstrated that a specific population of T cells, called "MAIT "played a major role in inflammation and fibrosis associated with chronic liver disease.
Dr Guillaume Canaud at the Necker-Enfants Malades Hospital – AP-HP, the Paris Descartes University, Inserm (INEM Institute Necker Enfants Malades – Centre for Molecular Medicine) and his team recently demonstrated the efficacy of a novel medication, a specific inhibitor called BYL719, in a cohort of 19 patients treated at the Necker-Enfants Malades Hospital – AP-HP and suffering from CLOVES Syndrome (Congenital Lipomatous Overgrowth, Vascular Malformation, Epidermal Naevi) or similar...
Numerous compounds are involved in the complex interactions that exist between our body and its microbiota. One of these is the essential amino acid, tryptophan. On June 13, 2018, in the journal Cell Host and Microbe, a team from Inra, AP-HP, Sorbonne Université and Inserm gathered the most recent advances concerning the central role of tryptophan in the dialog with our gut microbiota. Data which opens opportunities for research...
Do you tend to go for cake or vegetables? If you sometimes find it difficult to eat healthily, a study conducted by a team of researchers from Inserm, CNRS and Sorbonne Université, including Liane Schmidt and Hilke Plassmann, at the Brain & Spine Institute (ICM) has established a link between the anatomy of certain regions of our brain and our ability to control our food choices. These results were...
With Immunoscore, a test devised by a team of researchers from Inserm and Université Paris Descartes and doctors from the Paris AP-HP hospitals, disease progression in patients with colon cancer can now be defined more accurately. According to an international study conducted in more than 2,500 patients, Immunoscore has proved effective in predicting which patients are at high risk of tumor recurrence and, as such, would benefit from intensified...
While Bacillus cereus is well known as a source of food infections, researchers from INRA and ANSES, working with doctors at nine French hospitals[1] including those in the Paris Public Hospital System (AP-HP), have demonstrated for the first time that this bacterium is also responsible for inter- and intra-hospital nosocomial contamination. This study, conducted in 39 patients between 2008 and 2012, also found strains of B. cereus in the hospital environment capable of causing...