- Press releases - 23.07.2018
In Mice, Exposure to Chlordecone has Transgenerational Effects on Sperm Production
A study coordinated by Inserm researchers at the Research Institute for Environmental and Occupational Health in Rennes shows that exposing pregnant mice to chlordecone affects the third generation of their male progeny
- Press releases - 20.07.2018
When a Gut Bacterium Aggravates Metabolic Syndrome and a Probiotic Relieves It
While it is evident that obesity, type 2 diabetes and other metabolic complications are current public health issues, their prevalence is much less clear. A team of researchers from Inra, Danone, the Paris public hospital system (AP-HP), Inserm and Sorbonne Université have recently revealed, in an in vivo preclinical study, that the metabolic disorders linked to a high fat diet are aggravated by the proliferation of Bilophila wadsworthia, a pro-inflammatory gut bacterium which contributes to the deterioration of the intestinal barrier. These effects are attenuated by a probiotic bacterium known as Lactobacillus rhamnosus CNCM I-3690. The findings of this study pave the way for the development of nutritional approaches and probiotics which target the microbiota. They were published on July 18, 2018 in Nature Communications.
- Press releases - 11.07.2018
Obesity: Using the Microbiota to Fight the Harmful Effects of Fatty Liver
Day after day, the microbiota continues to yield its secrets. In a new study published in Nature Medicine, Rémy Burcelin, Inserm Research Director at the Institute of Cardiovascular and Metabolic Diseases (Inserm/UPS) along with researchers from Inserm Paris, Imperial College London, Girona Hospital and University of Rome Tor Vergata, show how certain gut bacteria cause the accumulation of fat in the liver and play a major role in fatty liver disease (hepatic steatosis). This research could ultimately lead to the availability of biomarkers to predict the disease and proposed therapeutic solutions based on nutritional, and pharmacological approaches and a new generation of probiotics.
- Press releases - 02.07.2018
Chronic liver disease: discovery of the role of T cell mucosa-associated invariant (MAIT) in inflammation and fibrosis
In collaboration with the team “Inflammation and stress in liver disease” of the Research Center for Inflammation (UMR 1149-Inserm-Université Paris Diderot), teams of Hepatology Services, anesthesia and resuscitation ‘pathology Beaujon hospital AP-HP, Paris Diderot University and the Cochin Institute (1016 UMR Inserm-University Paris Descartes), demonstrated that a specific population of T cells, called “MAIT “played a major role in inflammation and fibrosis associated with chronic liver disease.
- Press releases - 01.07.2018
Cost-effective universal screening for hepatitis C in France
An estimated 75 000 people in France are unaware they are infected by hepatitis C virus. An ANRS-funded study by Sylvie Deuffic-Burban, a research associate at IAME (Infection, Antimicrobials, Modeling, Evolution) (Inserm – Université Paris Diderot – Université Paris 13), and her team shows that a universal screening strategy applied to hepatitis C is cost-effective and improves life expectancy in those infected, compared with targeted screening. These modeling results will be published on 1st July 2018 in Journal of Hepatology.
- Press releases - 28.06.2018
A new twist on how parasites invade host cells
Des chercheurs du CNRS, de l’Inserm et de l’Université Grenoble Alpes viennent de décrypter les mécanismes déployés par le parasite Toxoplasma gondii pour pénétrer dans les cellules de ses hôtes. À l’aide d’une imagerie quantitative à haute vitesse et haute résolution, ils ont identifié un mouvement singulier du parasite qui lui permet de fermer derrière lui la porte qu’il a créée pour rentrer dans la cellule-hôte et s’y nicher. Ces travaux, à l’interface de la biologie cellulaire, de la parasitologie et de la biophysique, sont publiés dans Cell Host & Microbes le 28 juin 2018.
- Press releases - 28.06.2018
A Summer of Science and Art with the Participation of Inserm
Inserm has long played a proactive role in scientific outreach in order to share science and biomedical research advances with the general public. And this summer 2018 will be no exception, with its host of events in which art and science will meet, in which our researchers will participate in La recherche de l’art #7 in Arles, Binôme in Avignon, and the Science in The City festival in Toulouse. The diary of Inserm’s scientific and cultural events, which include a photography exhibition, play, and visual performances, is presented below.
- Press releases - 21.06.2018
Hypertension: An international study shows the blood pressure benefit of endovascular renal denervation focused ultrasound in patients receiving no antihypertensive drug
After reporting the first positive results of renal denervation in blood pressure (HBP) resistant in the journal The Lancetin 2015, the team of the Center of Excellence in Hypertension and CIC1418 APHP-INSERM led by Dr. Michel Azizi and that of the interventional radiology department led by Prof. Marc Sapoval from European Georges Pompidou Hospital, AP-HP , obtained promising new results in hypertensive patients receiving no antihypertensive therapy as part of an international study. They provide, for the first time, evidence of the reduction in blood pressure after renal denervation focused ultrasound in this indication. The findings of the RADIANCE-SOLO study, coordinated by the European Hospital Georges Pompidou, AP-HP, were presented at EuroPCR in Paris and at the Congress of the European Society of Hypertension in Barcelona. They are published in the journal The Lancet . This opens new perspectives for treatment in this disease that affects 30% of the French population to consider in the future an alternative to drug therapy for some patients.
- Press releases - 21.06.2018
How does air pollution affect the placenta ?
Researchers from Inserm, CNRS and Université Grenoble Alpes working at the Institute for Advanced Biosciences (Joint Research Unit 1209) have analyzed the consequences of environmental exposure in utero using data collected from a cohort of 668 women. Exposure to atmospheric pollution is associated with epigenetic modifications in the placenta, presenting a risk to the fetus. These findings were published in Environment International on June 21, 2018.
- Press releases - 20.06.2018
Research into a Ricin Antidote – What’s New?
Back in 2016, a team from Inserm had made a major contribution to the development of an aerosol capable of rapidly administering, into the deepest reaches of the lungs, an antidote to ricin. Ricin is highly toxic when inhaled and dreaded in the event of a bioterrorism attack.