Category Archives: Cell biology, development and evolution

Persistence of rituximab-resistant memory B cells contributes to relapses in adult patients with immunologic thrombocytopenia

lymphocytes B

Teams of researchers studied the presence of self-reactive memory B lymphocytes before and after treatment with rituximab in adult patients with thrombocytopenia immunologic disease (ITP), a rare autoimmune disease. The results of this study show that a fraction of memory B lymphocytes self-reactive towards platelet antigenesist treatment with rituximab, persist in the spleen for several months and participates in relapses. The discovery of these cells could open up new therapeutic avenues.

Maladie de Huntington : L’alliance de la génomique et de l’intelligence artificielle met en avant un rôle central des pertes de résilience neuronale

Huntingto

La perte des mécanismes de compensation et de résilience neuronale à la maladie de Huntington serait le moteur principal de l’évolution de cette maladie au niveau moléculaire. Publiés dans eLife le 23 février 2021 et basés sur une méthode originale d’apprentissage automatique pour l’analyse précise de gros volumes de données génomiques obtenues dans des modèles de la maladie, ces travaux suggèrent que rétablir la résilience neuronale est une piste thérapeutique importante pour une intervention précoce afin de lutter contre cette maladie.

A Major Breakthrough in Understanding the Predisposition of Newborns to Group B Streptococcal Meningitis

Every year throughout the world, Group B Streptococcal (GBS) meningitis affects thousands of newborns. Often fatal, the disease can also lead to severe after-effects in survivors.

Maturation et persistance de la réponse lymphocytaire B mémoire anti-SARS-CoV-2

Une étude sur la mémoire immunitaire montre la maturation et la persistance de la mémoire immunitaire B contre le virus SARS-CoV-2 au cours du temps.

Rendre le cerveau résilient aux maladies neurodégénératives : une nouvelle piste identifiée dans la maladie de Huntington

Une équipe de recherche vient de mettre en évidence que les neurones du cerveau peuvent devenir sénescents très tôt dans la maladie de Huntington et que l’inhibition des gènes pro-sénescence possèdent des effets neuro-protecteurs. Ces travaux suggèrent que les neurones sont victimes d’un vieillissement cellulaire accéléré dans la maladie de Huntington et fournissent de nouvelles pistes thérapeutiques pour une intervention précoce contre cette maladie.

Food Emulsifiers Increase Pathogenicity of Certain Bacteria and Risk of Intestinal Inflammation

Diet is believed to play a role in triggering intestinal inflammation that can lead to the development of certain conditions, such as Crohn’s disease. Researchers from Inserm, CNRS and Université de Paris have shown that the emulsifiers present in many processed foods could have a harmful impact on specific bacteria in the gut microbiota, leading to chronic inflammation.

The Placenta Could Retain a Memory of Tobacco Exposure Prior to Pregnancy

A study is showing for the first time that tobacco consumption, even when stopped before pregnancy, can have an impact on the placenta. Smoking not just during but also before pregnancy leads to epigenetic modifications (DNA methylation) which could have consequences on its course.

Blood Stem Cell Immune Memory: A New Research Avenue in COVID-19

Blood stem cells have a surprising ability. In addition to ensuring the continuous renewal of blood cells, they keep track of past infections so that faster and more effective immune responses can be triggered in the future.

A New Blood Component Revealed

Does the blood we thought to know so well contain elements that had been undetectable until now? The answer is yes, according to a team of researchers which has revealed the presence of whole functional mitochondria in the blood circulation. These organelles that are responsible for cellular respiration had hitherto only been found outside cells in very specific cases.

Skin graft: a new molecular target for activating stem cells

A joint study led by several teams open skin regeneration medecine to new insights.

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