Category Archives: Cell biology, development and evolution

Skin graft: a new molecular target for activating stem cells

A joint study led by several teams open skin regeneration medecine to new insights.

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Assistance médicale à la procréation : la congélation embryonnaire associée à une augmentation du poids de naissance

Des équipes du CHU de Montpellier et de l’Inserm publient dans la revue Scientific Reports une étude portant sur une différence de poids de plus de 250 grammes entre les enfants nés à la suite d’une congélation embryonnaire et ceux issus d’embryons « frais ».

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Une étude confirme l’intérêt du test sanguin de dépistage des infections virales VirScan dans le suivi des patients greffés du rein

Le test sanguin VirScan permet de détecter les infections virales, responsables de complications tumorales et infectieuses, fréquentes après une greffe et susceptibles d’avoir un impact sur le fonctionnement du greffon.

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Fertility and endometriosis: a research update from Inserm

Today, around 1 in 8 couples seek help because they are struggling to conceive. Infertility has therefore become a public health problem, and the scientific community is rallying in response.

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Nanoblades: shuttles for genome surgery

Researchers are now able to edit the genome with precision using the “gene editing scissors” of CRISPR-Cas9, which is a highly promising tool for gene therapy. The technical challenge now is to get this tool into the genome of certain cells. With this in mind, a joint team from Inserm, the CNRS, the Université Claude Bernard Lyon 1, and the École Normale Supérieure de Lyon, working within the International Center for Infectiology Research (CIRI), have developed capsules that allow CRISPR-Cas9 to reach the target DNA: Nanoblades.

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A Gene Therapy Tested in the Treatment of Myotubular Myopathy

Inserm and CNRS researchers from the Institute of Genetics and Molecular and Cellular Biology (Inserm/CNRS/Université de Strasbourg) have discovered how myotubularin – a protein deficient in myotubular myopathy – interacts with amphiphysin 2 and suggest targeting the latter in order to treat patients.

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Alzheimer’s: identification of potential target protein aggregates for treating the disease

La propagation des agrégats de la protéine Tau dans le cerveau contribue à la progression de la maladie d’Alzheimer. Des chercheurs du Laboratoire des maladies neurodégénératives : mécanismes, thérapies, imagerie (CNRS/CEA/Université Paris-Sud, MIRCen), en collaboration avec l’Ecole normale supérieure, Sorbonne Université et l’Inserm, viennent d’identifier les cibles de ces agrégats. Publiés dans EMBO Journal le 10 janvier 2019, ces travaux permettront la conception d’outils capables de bloquer ces éléments clés dans la propagation des agrégats et de contrecarrer ainsi leur effet pathologique.

Also posted in Press releases, Genetics, genomics and bioinformatics, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Discovery of novel mechanisms that cause migraines

Researchers at CNRS, Université Côte d’Azur and Inserm have demonstrated a new mechanism related to the onset of migraine. In fact, they found how a mutation, causes dysfunction in a protein which inhibits neuronal electrical activity, induces migraines. These results, published in Neuron on December 17, 2018, open a new path for the development of anti-migraine medicines.

Also posted in Genetics, genomics and bioinformatics, Neurosciences, cognitives sciences, neurology and psychiatry | Tagged | Comments closed

Myopathie : un gain de force musculaire chez la souris

Des souris atteintes de dystrophie musculaire de Duchenne récupèrent plus de 20% de force musculaire grâce à la metformine.

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Cancer under pressure: visualizing the activity of the immune system on tumor development

As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology on November 23, 2018.

Also posted in Cancer, Press releases, Genetics, genomics and bioinformatics, Immunology, inflammation, infectiology and microbiology, Health technologies | Tagged | Comments closed
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