Category Archives: Immunology, inflammation, infectiology and microbiology

Ebola Survivors Present Severe Immune System Abnormalities Two Years After Recovery

Four years after the end of the Ebola epidemic in West Africa, and as it continues to wreak havoc in the Democratic Republic of Congo, the scientific community wonders about the after-effects that may remain among survivors. To learn more, researchers from Inserm and Université Paris-Est Créteil at the Institute for Vaccine Research decided to look at how their immune profiles had changed.

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Une étude préclinique montre que l’hydroxychloroquine n’a pas d’effet antiviral contre le SARS-CoV-2 in vivo

Les résultats d’une étude sur les effets de l’hydroxychloroquine, associée ou non à l’azithromycine, dans un modèle d’infection expérimentale chez le macaque par le virus SARS-CoV-2, l’agent infectieux responsable de la pandémie de la COVID-19, font l’objet d’une publication dans la revue Nature le 22 juillet 2020.

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Microbiote : la géographie intestinale influence les interactions entre les bactéries et leurs virus

Les bactéries du microbiote sont soumises à la prédation de leurs virus, les bactériophages, mais une partie d’entre elles peut trouver refuge dans le mucus qui recouvre les tissus de l’intestin, permettant de garder les populations de bactériophages et de bactéries en équilibre.Telles sont les conclusions d’une étude dirigée par Laurent Debarbieux, directeur de recherche et responsable du laboratoire Bactériophage, bactérie, hôte à l’Institut Pasteur avec Luisa De Sordi, maître de conférences Sorbonne Université au Centre de recherche Saint Antoine (Sorbonne Université / Inserm).

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Menstrual Toxic Shock Syndrome: Encourage Proper Tampon Use to Limit Risks

In a study published in March 2020 in the journal EClinical Medicine, Prof. Gérard Lina’s team suggests simple measures to put in place for better tampon use during menstruation.

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COVID-19: Vaccine Research at Inserm

Developing an effective and safe vaccine is one of the priority objectives in the fight to contain the COVID-19 pandemic. At Inserm, a dozen teams are involved in vaccine research projects. In particular, three initiatives have recently been selected by France’s Ministry of Higher Education, Research and Innovation on the advice of the COVID-19 Analysis, Research and Expertise Committee (CARE) and Inserm’s REACTing consortium, in order to receive special support and thus accelerate research.

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Cardiac arrest outside the hospital during the peak of the COVID-19 epidemic: studies highlight pulmonary embolism as the main determinant

Des investigateurs français de l’Institut médico-légal de Paris, de l’Inserm, du service de radiologie de l’hôpital Sainte-Anne/GHU Paris, du département d’anesthésie-réanimation des hôpitaux de l’AP-HP Saint-Louis et Lariboisière, d’Université de Paris, et du CNRS ont fait l’hypothèse que les arrêts cardiaques en dehors de l’hôpital pendant le pic de la pandémie de Covid-19 pourraient être en partie dus à des embolies pulmonaires massives. Le détail de ces travaux a été publié le 28 mai 2020 dans l’European Journal of Heart Failure.

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Inflammatory Bowel Disease: Immune Cells Spearheading the Cure

Inflammations of the intestine affect many patients, often with reduced therapeutic prospects. The role of iron in these inflammatory processes is increasingly well documented, opening up new avenues of treatment. A collaborative study shows that the hormone that regulates iron levels in the body is produced by immune cells during inflammation of the intestine, and that it helps repair damage to the intestinal mucosa.

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Hépatite B : identification d’une nouvelle molécule produite par les cellules hôtes favorisant l’infection

Une équipe de recherche a réussi à identifier une nouvelle molécule favorisant le développement du virus dans les cellules infectées, qui pourrait, à l’avenir, ouvrir de nouvelles perspectives thérapeutiques.

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Covid-19: Publication of a prospective observational study in the journal BMJ in children with hyper-inflammatory syndrome related to Kawasaki disease

characteristics of children and adolescents hospitalized in a context of Kawasaki disease-like syndrome in a COVID-19 epidemic context, with a systemic hyper-inflammatory expression.

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Paris and Its Suburbs: Twice as Many Cardiac Arrests During Lockdown

Indirect consequences of the COVID-19 pandemic on the healthcare system and the management of other diseases are beginning to emerge.

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